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Cyclobenzaprine Hcl Er Capsule — prescription drug image

Cyclobenzaprine Hcl Er

Cyclobenzaprine HCl ER 15MG

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What is Cyclobenzaprine Hcl Er?

Cyclobenzaprine HCl ER (extended-release) is a muscle relaxant commonly prescribed to relieve muscle spasms associated with acute, painful musculoskeletal conditions. It works by blocking nerve impulses (or pain sensations) that are sent to your brain. Cyclobenzaprine is typically used in conjunction with rest and physical therapy to treat skeletal muscle conditions.

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What is Cyclobenzaprine Hcl Er ?

Cyclobenzaprine HCl ER (extended-release) is a muscle relaxant commonly prescribed to relieve muscle spasms associated with acute, painful musculoskeletal conditions. It works by blocking nerve impulses (or pain sensations) that are sent to your brain. Cyclobenzaprine is typically used in conjunction with rest and physical therapy to treat skeletal muscle conditions.
  • Fast, pounding, or uneven heartbeat
  • Severe drowsiness, fainting, or confusion
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Anxiety, restlessness, fever, sweating, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Tell your doctor if you are pregnant or breastfeeding, or if you have liver problems, congestive heart failure, heart rhythm problems, a recent heart attack, overactive thyroid, or a history of glaucoma or trouble urinating.
  • This medicine may cause the following problems:Serotonin syndrome, when taken with certain medicines
  • This medicine may make you dizzy or drowsy. Do not drive or doing anything that could be dangerous until you know how this medicine affects you.
  • Call your doctor if your symptoms do not improve or if they get worse.
What is cyclobenzaprine HCl ER used for?
It is FDA-approved as an add-on to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions. The extended-release capsule is taken once a day, and the labeling limits use to two to three weeks because benefit beyond that has not been established. It is not shown to help spasticity from cerebral or spinal cord disease, and it is not for children with cerebral palsy.
What is the difference between cyclobenzaprine ER and regular cyclobenzaprine?
Both contain the same medicine. The extended-release capsule comes in 15 mg and 30 mg and is taken once daily, with or without food. The immediate-release tablet is taken three times a day. The ER form is a capsule; the regular form is a tablet. Which one you get is your prescriber's decision, and the cash price of each can be quite different, so it is worth comparing.
How long does cyclobenzaprine ER stay in your system?
The labeling reports a half-life of about 32 hours in younger subjects after a dose of the extended-release capsule, and about 50 hours in subjects over 65, whose plasma exposure also runs higher. A half-life is how long it takes the body to clear about half the drug, so it takes several days for a medicine like this to leave the body fully. That longer exposure in older adults is one reason the ER capsule is specifically not recommended for elderly patients.
Is cyclobenzaprine a controlled substance or narcotic?
No. Cyclobenzaprine is not a federally controlled substance and it is not a narcotic or opioid. It is a centrally acting skeletal muscle relaxant that is structurally a tricyclic compound, closely related to tricyclic antidepressants like amitriptyline. It still causes marked drowsiness and increases the effects of alcohol and other CNS depressants, so it deserves the same care you would give any sedating medication.
Can you take cyclobenzaprine ER at night for sleep?
Cyclobenzaprine ER is not approved for sleep, and it should only be used the way your prescriber directs. The extended-release capsule is a once-daily medicine approved for short-term relief of muscle spasm from acute musculoskeletal conditions. It does cause marked drowsiness and dizziness, which is a side effect rather than an approved use. Ask your prescriber about the timing that is right for you, and do not drive until you know how it affects you.
How much does Cyclobenzaprine Hcl Er cost without insurance?
The price of Cyclobenzaprine Hcl Er without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Cyclobenzaprine Hcl Er?
Common side effects of Cyclobenzaprine Hcl Er may include: Fast, pounding, or uneven heartbeat, Severe drowsiness, fainting, or confusion, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Anxiety, restlessness, fever, sweating, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Cyclobenzaprine Hcl Er?
Generic versions may be available for Cyclobenzaprine Hcl Er. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Cyclobenzaprine Hcl Er on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Cyclobenzaprine Hcl Er?
The cheapest pharmacy for Cyclobenzaprine Hcl Er depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Cyclobenzaprine Hcl Er near you.

Cyclobenzaprine Hcl Er Coupons & Prices

Cyclobenzaprine HCl ER 15MG

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Cyclobenzaprine Hcl Er Capsule — prescription drug image
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Cyclobenzaprine Hcl Er 15mg (7)
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Cyclobenzaprine Hcl Er prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
15mg · Capsule 30 $1,164.99 $52.56
30mg · Capsule 30 $1,164.99 $40.28

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

If you are looking for a cyclobenzaprine HCl ER coupon, Rx.com compares cash prices at more than 60,000 pharmacies so you can see what this prescription costs near you today. Cyclobenzaprine hydrochloride extended-release is the generic form of the brand Amrix, a once-daily muscle relaxant capsule, and an FDA-approved generic is available. Cash prices for the same capsule can differ quite a bit from one pharmacy to the next, even within a few miles, so comparing is worth the minute it takes. Enter your ZIP code above to see today's price and print, text, or email a free coupon to bring to the counter.

What is cyclobenzaprine HCl ER and how does it work?

Cyclobenzaprine hydrochloride extended-release is a centrally acting skeletal muscle relaxant, sold under the brand name Amrix. Structurally it is a tricyclic compound, closely related to tricyclic antidepressants such as amitriptyline. It works in the central nervous system rather than directly on the muscle itself.

The FDA approves it as an add-on to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions. The extended-release capsule comes in 15 mg and 30 mg strengths and is taken once daily, with or without food. The labeling limits treatment to two to three weeks, because effectiveness beyond that has not been established. It is not shown to help spasticity caused by cerebral or spinal cord disease, and it is not for children with cerebral palsy.

What cyclobenzaprine HCl ER costs without insurance

Because a generic is available, most people filling this prescription are buying the generic capsule rather than brand-name Amrix. What surprises many people is how much the cash price still varies: two pharmacies in the same town can quote noticeably different prices for the identical 15 mg or 30 mg capsule. Cash price is set by each pharmacy, not by the drug itself, so there is no single "right" number to expect.

That is exactly why comparing matters. Rx.com checks cash prices across more than 60,000 U.S. pharmacies, including the large chains, grocery pharmacies, and independents. Enter your ZIP above to see today's price at pharmacies near you, then use the free Rx.com coupon at the counter. If you have insurance, it is always worth asking the pharmacist to compare your copay against the cash coupon price, since sometimes the coupon is the better deal and sometimes your plan is.

Cyclobenzaprine ER vs. other muscle relaxants

The main comparison is with plain cyclobenzaprine, the immediate-release tablet, which is dosed three times a day. The extended-release capsule delivers the same drug once daily. Both are used for short-term relief of muscle spasm from acute musculoskeletal conditions. The immediate-release tablet is the far more commonly filled version, and its cash price and the ER capsule's cash price can be very different, so it is worth checking both if your prescriber says either would work for you.

Other muscle relaxants your prescriber may consider include tizanidine, methocarbamol, baclofen, and metaxalone. These are different medicines with different labels, side effects, and dosing, not interchangeable substitutes. Only your prescriber can decide which one fits your situation, but if more than one is an option, comparing prices before you fill can save you money.

Safety information to know

Cyclobenzaprine ER has no boxed warning, but it does have important restrictions. It should not be used with MAO inhibitors, or within 14 days of stopping one. It is contraindicated in hyperthyroidism, during the acute recovery phase of a heart attack, and in people with arrhythmias, heart block or other conduction disturbances, or congestive heart failure. Because it is structurally related to tricyclic antidepressants, it carries comparable risks including arrhythmias, fast heartbeat, and changes in heart conduction. Serotonin syndrome has been reported when it is combined with serotonergic drugs such as SSRIs, SNRIs, tramadol, triptans, and MAOIs, so tell your prescriber and pharmacist everything you take.

It causes marked drowsiness and dizziness. Do not drive or operate machinery until you know how it affects you, and be aware that it increases the effects of alcohol, barbiturates, and other CNS depressants. Its anticholinergic effects call for caution if you have urinary retention, angle-closure glaucoma, or increased pressure in the eye; dry mouth is the most common side effect. Importantly, the ER capsule is specifically not recommended for elderly patients, whose plasma levels run higher and whose half-life is about 50 hours in subjects over 65 versus 32 hours in younger subjects, and it appears on the Beers list of potentially inappropriate medications for older adults. It is also not recommended in mild, moderate, or severe liver impairment, where levels run substantially higher. This is general information, not medical advice; talk with your provider or pharmacist about your own health.

Sources & accuracy

This Cyclobenzaprine Hcl Er information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Cyclobenzaprine Hcl Er on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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