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Simponi Aria Vial — prescription drug image

Simponi Aria

Simponi Aria 4ML of 50MG/4ML

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What is Simponi Aria?

Simponi Aria is a TNF alfa inhibitor drug used in patients diagnosed with rheumatoid arthritis. There is not a Simponi Aria generic drug currently available on the market. Simponi Aria costs around $1,730 for a supply of 1, 50 mg/4 ml vial, but luckily there are ways to save money. You can use our Rx.com Simponi Aria savings card to save significantly on the retail price at participating pharmacies near you.

Prescription savings · · · ·

What is Simponi Aria ?

Simponi Aria is a TNF alfa inhibitor drug used in patients diagnosed with rheumatoid arthritis. There is not a Simponi Aria generic drug currently available on the market. Simponi Aria costs around $1,730 for a supply of 1, 50 mg/4 ml vial, but luckily there are ways to save money. You can use our Rx.com Simponi Aria savings card to save significantly on the retail price at participating pharmacies near you.
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Warm, red, swollen, or painful skin, blisters, skin sores
  • Change in how much or how often you urinate, painful urination
  • Fever, chills, cough, runny or stuffy nose, sore throat, body aches
  • Swollen glands in the neck, underarms, or groin
  • Trouble breathing, chest pain, uneven heartbeat
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet
  • Changes in vision
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Unusual bleeding, bruising, or weakness
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, cancer, heart failure, diabetes, COPD, psoriasis, problems with your immune system, granulomatosis with polyangiitis, optic neuritis, multiple sclerosis, or a history of Guillain-Barré syndrome. Tell your doctor if you have any type of infection (including hepatitis B or tuberculosis) or an infection that keeps coming back. Also, tell your doctor if you are allergic to latex.
  • This medicine may cause the following problems:Increased risk for serious infectionsIncreased risk of certain cancers (including lymphoma, leukemia, colon cancer, skin cancer)Heart problems, including heart failureLiver problemsLupus-like syndrome
  • You will need to have a skin test for tuberculosis (TB) before you start this medicine. Tell your doctor if you or anyone in your home has ever had a positive TB skin test or been exposed to TB.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Injection routeThrow away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Unusual bleeding, bruising, or weakness
  • Warm, red, swollen, or painful skin, blisters, skin sores
What is Simponi Aria used for?
Simponi Aria (intravenous golimumab) is FDA-approved to treat moderately to severely active rheumatoid arthritis in adults, used in combination with methotrexate; active psoriatic arthritis in patients 2 years and older; active ankylosing spondylitis in adults; and active polyarticular juvenile idiopathic arthritis in patients 2 years and older. It is a TNF blocker, meaning it reduces the inflammation that causes joint pain, swelling, and damage in these conditions. It is given as a 30-minute IV infusion by a healthcare professional at week 0 and week 4, then every 8 weeks.
How is Simponi Aria different from Simponi?
Both contain the same active drug, golimumab, but they are given differently and are not approved for exactly the same conditions. Simponi Aria is an intravenous infusion given in a clinic or infusion center, dosed by body weight every 8 weeks after the two starter doses. Simponi is an under-the-skin injection you can give yourself at home. Simponi is also approved for ulcerative colitis; Simponi Aria is not. They are not interchangeable, and switching between them is a decision for your prescriber.
How much does Simponi Aria cost without insurance, and is there a copay card?
Simponi Aria is an infused biologic, so it is usually billed through your medical benefit by the clinic or infusion center rather than filled at a pharmacy, and the amount you owe depends on your plan and the site of care. Johnson & Johnson runs an official savings program for Simponi Aria through its manufacturer site and the J&J withMe support program; like most manufacturer copay programs it is generally limited to people with commercial insurance, and eligibility and terms vary. If you are uninsured, on Medicare, or not eligible for the card, ask about the Johnson & Johnson Patient Assistance Foundation and independent copay foundations. Ask your infusion center for a written cost estimate before your first infusion. A free Rx.com cash coupon can help with the retail-pharmacy prescriptions you take alongside it, such as methotrexate; retail prices vary by pharmacy, so enter your ZIP above to compare today's price.
What are the most common side effects and risks of Simponi Aria?
Commonly reported problems include upper respiratory infections, other infections, and infusion-related reactions. The label carries a boxed warning for serious infections, including tuberculosis (often reactivation of a latent infection), invasive fungal infections, and other bacterial, viral, and opportunistic infections, and a boxed warning about malignancy, including lymphoma reported in children and adolescents treated with TNF blockers. Other warnings include hepatitis B reactivation, new or worsening heart failure, demyelinating disease, low blood cell counts, lupus-like syndrome, and hypersensitivity reactions. You should be tested for TB before starting and should avoid live vaccines during treatment. Tell your doctor right away about fever, cough, night sweats, or unexplained weight loss. This is not a complete list; talk with your healthcare provider.
Is there a generic or biosimilar version of golimumab?
There is no true generic golimumab, because golimumab is a biologic. Biologics get biosimilars instead. In May 2026 the FDA approved the first golimumab biosimilars, golimumab-sldi, sold as Immgolis Intri (the IV product) and Immgolis (the subcutaneous product) from Bio-Thera Solutions and Accord BioPharma, and both were approved as interchangeable. As of July 2026 they are approved but have not launched, so Simponi Aria remains the only IV golimumab available in US infusion centers. The manufacturer has said it plans a US launch by late 2026, but patent litigation brought by Janssen is still pending, including a request to block the launch that a court is expected to hear in the fall of 2026, so the date could slip. Once biosimilars launch, competition may lower cost. Ask your rheumatologist and your insurer whether a biosimilar has become available and whether it is covered.
How much does Simponi Aria cost without insurance?
The price of Simponi Aria without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Simponi Aria?
Common side effects of Simponi Aria may include: Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes, Warm, red, swollen, or painful skin, blisters, skin sores, Change in how much or how often you urinate, painful urination, Fever, chills, cough, runny or stuffy nose, sore throat, body aches, Swollen glands in the neck, underarms, or groin. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Simponi Aria?
Generic versions may be available for Simponi Aria. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Simponi Aria on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Simponi Aria?
The cheapest pharmacy for Simponi Aria depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Simponi Aria near you.

Simponi Aria Coupons & Prices

Simponi Aria 4ML of 50MG/4ML

Prescriptions & Refills
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Simponi Aria Vial — prescription drug image
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Looking for a Simponi Aria coupon? Simponi Aria is the intravenous (IV) form of golimumab, a TNF-blocker biologic given as a 30-minute infusion for rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and polyarticular juvenile idiopathic arthritis. Because it is infused in a clinic or infusion center rather than picked up at a pharmacy counter, the way you pay for it is different from a typical prescription, and there is no generic golimumab on the market today. Below we explain how Simponi Aria works, how the manufacturer's savings program compares with an Rx.com cash coupon, what the biosimilars approved in 2026 could mean for cost, and the safety points to review with your doctor. For any medicine you do fill at a retail pharmacy, enter your ZIP above to see today's price at nearby pharmacies.

What is Simponi Aria and how does it work?

Simponi Aria is the brand name for golimumab given by intravenous infusion. It is a monoclonal antibody that blocks tumor necrosis factor alpha (TNF-alpha), a protein in the immune system that drives the inflammation, joint swelling, pain, and joint damage seen in certain autoimmune diseases. By binding TNF-alpha, Simponi Aria turns down that inflammatory signal. It belongs to the same broad class as Humira, Enbrel, Remicade, and Cimzia.

The FDA-approved uses on the current label are moderately to severely active rheumatoid arthritis in adults (used together with methotrexate), active psoriatic arthritis in patients 2 years and older, active ankylosing spondylitis in adults, and active polyarticular juvenile idiopathic arthritis in patients 2 years and older. Simponi Aria is given by a healthcare professional as a 30-minute IV infusion, dosed by body weight at week 0 and week 4, then every 8 weeks. Important: the IV form is not approved for ulcerative colitis. Only the under-the-skin injection, Simponi, carries that indication.

Simponi Aria cost: manufacturer savings card vs. an Rx.com cash coupon

Simponi Aria is an infused biologic, so it is usually billed through your medical benefit (the clinic or infusion center buys the drug and bills your plan), not through your pharmacy benefit. That means the price is set by your plan, the site of care, and the infusion facility's charges rather than by a pharmacy shelf price. What you owe can vary a lot depending on where you get infused, so ask the infusion center for a written cost estimate before your first appointment.

Your main cost tools, and how they differ:

  • Manufacturer savings program. Johnson & Johnson runs an official copay savings program for Simponi Aria (information is on the manufacturer's own Simponi Aria site and through its J&J withMe patient support program). Programs like this are generally limited to people with commercial insurance, and eligibility, caps, and terms vary and change over time. People with Medicare, Medicaid, TRICARE, VA coverage, or no insurance are typically not eligible.
  • Patient assistance. If you are uninsured or underinsured and cannot afford treatment, the Johnson & Johnson Patient Assistance Foundation and the J&J withMe support line can screen you for free-medicine or other assistance programs. Independent nonprofit foundations that help with autoimmune-disease copays are another route worth asking your rheumatology office about.
  • An Rx.com cash coupon. Our free coupon is a cash-discount card accepted at retail pharmacies. It will not usually apply to a drug infused in a clinic, but it is useful for the rest of your regimen, including the methotrexate, folic acid, or other prescriptions often taken alongside Simponi Aria. Unlike a manufacturer card, it does not require commercial insurance, so it can be used if you are uninsured, on Medicare, or if a copay card is declined. Retail prices vary by pharmacy, so it is worth comparing before you fill: enter your ZIP above to see today's price at pharmacies near you.

You cannot combine a cash coupon with insurance on the same fill: at the counter you either run it through your plan or use the coupon as a cash payment, whichever is cheaper that day.

Is there a generic or biosimilar golimumab?

There is no true generic version of golimumab, because it is a biologic, not a simple small-molecule drug. Biologics get biosimilars instead of generics. In May 2026 the FDA approved the first golimumab biosimilars, golimumab-sldi, cleared as interchangeable and marketed as Immgolis Intri (the IV form, comparable to Simponi Aria) and Immgolis (the subcutaneous form, comparable to Simponi), from Bio-Thera Solutions and Accord BioPharma.

Being approved is not the same as being available. As of July 2026 neither product has launched in the United States, so Simponi Aria remains the only IV golimumab you can actually receive in a US infusion center. Accord has said it is targeting US availability by late 2026, but that timing is not guaranteed: Janssen sued Bio-Thera and Accord in March 2026 over 17 patents and has a motion pending that asks the court to block a launch, with a hearing expected in the fall of 2026. Depending on how that turns out, the launch could be delayed.

When biosimilars do launch, they typically create price competition and can lower what plans and patients pay over time. Ask your rheumatologist and your infusion center whether a golimumab biosimilar has become available and whether your plan prefers it. Do not switch products on your own; substitution of an infused biologic is a decision for your prescriber and your plan.

Alternatives and how Simponi Aria compares

Simponi Aria (IV golimumab) and Simponi (subcutaneous golimumab) contain the same active drug but are not interchangeable products: they have different dosing schedules, different approved uses (only the subcutaneous form is approved for ulcerative colitis), and different ways of being administered and billed. Simponi Aria is infused by a professional every 8 weeks after the starter doses; Simponi is a self-injection given at home.

If a TNF blocker is not the right fit, or if one stops working, rheumatologists commonly consider other options depending on your diagnosis:

  • Other TNF blockers: Humira (adalimumab), Enbrel (etanercept), Remicade (infliximab, also IV), Cimzia (certolizumab pegol)
  • Biologics with a different target: Orencia (abatacept), Actemra (tocilizumab)
  • Conventional DMARDs: methotrexate, which is often used with Simponi Aria in rheumatoid arthritis rather than instead of it, and which is available as a generic tablet (prices vary by pharmacy, so compare before you fill)

Adalimumab and infliximab have biosimilars on the US market (etanercept biosimilars are approved but not yet launched here), which is one reason your insurer may ask you to try one of them first. Which biologic is appropriate depends on your diagnosis, prior treatments, other health conditions, and your plan's coverage rules. Your rheumatologist decides that with you.

Safety: what to know before starting Simponi Aria

Simponi Aria carries a boxed warning, the FDA's strongest warning, covering two things. First, serious infections: because the drug suppresses part of the immune system, patients face a higher risk of serious infections that can lead to hospitalization or death, including tuberculosis (often reactivation of a hidden, latent infection), invasive fungal infections such as histoplasmosis and coccidioidomycosis, and other bacterial, viral, and opportunistic infections. Most reported cases occurred in people also taking immune-suppressing drugs such as methotrexate or corticosteroids. You must be tested for latent TB before starting, and treated for it if positive; testing continues during therapy. Treatment is stopped if a serious infection develops. Second, malignancy: lymphoma and other cancers, some fatal, have been reported in children and adolescents treated with TNF blockers, and a rare, aggressive cancer called hepatosplenic T-cell lymphoma has been reported with TNF blockers.

Other important label warnings include reactivation of hepatitis B in people who carry the virus, new or worsening congestive heart failure, demyelinating disease (such as multiple sclerosis, optic neuritis, or Guillain-Barre syndrome), low blood cell counts, lupus-like syndrome, and hypersensitivity or infusion reactions. Live vaccines should be avoided during treatment, and Simponi Aria should not be combined with other biologic DMARDs or with abatacept or anakinra. Call your doctor right away about fever, cough, night sweats, weight loss, unusual bruising or bleeding, new numbness or vision changes, or new swelling and shortness of breath. This page is general information, not medical advice. Review your full history, infections, and vaccination status with your healthcare provider before starting or continuing Simponi Aria.

Sources & accuracy

This Simponi Aria information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Simponi Aria on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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