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Spironolactone Tablet — prescription drug image

Spironolactone

Spironolactone 25MG

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What is Spironolactone?

Aldactone is a potassium-sparing diuretic (water pill) drug used to treat edema and hypertension. The generic version of Aldactone is Spironolactone. On average Aldactone is priced at about $18 for a supply of 30, 25 mg tablets. Luckily, you can use our Rx.com savings offer to receive an Aldactone discount of up to 80% off the retail price at participating pharmacies near you.

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What is Spironolactone ?

Aldactone is a potassium-sparing diuretic (water pill) drug used to treat edema and hypertension. The generic version of Aldactone is Spironolactone. On average Aldactone is priced at about $18 for a supply of 30, 25 mg tablets. Luckily, you can use our Rx.com savings offer to receive an Aldactone discount of up to 80% off the retail price at participating pharmacies near you.
  • Confusion, uneven heartbeat, trouble breathing, numbness or tingling in your hands, feet, or lips
  • Lightheadedness, dizziness, drowsiness, fainting
  • Dry mouth, increased thirst, muscle cramps, nausea, vomiting
  • Blistering, peeling, red skin rash
  • Muscle twitching
  • Blood in your stools or dark stools, vomiting blood or material that looks like coffee grounds
  • Increased hunger or thirst, change in how much or how often you urinate, unusual weight loss
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Unusual bleeding, bruising, or weakness
  • Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding, or if you have kidney disease, liver disease, diabetes, gout, or trouble urinating.
  • This medicine may cause the following problems:Low blood pressureKidney problemsElectrolyte imbalanceHigh uric acid and blood sugarGynecomastia (enlarged breast)
  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • Do not stop using the medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in the normal range. You may have to take blood pressure medicine for the rest of your life.
  • Tell any doctor or dentist who treats you that you are using this medicine.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Unusual bleeding, bruising, or weakness
What is spironolactone used for?
Spironolactone is FDA-approved to help treat heart failure (as add-on therapy to reduce the risk of death and hospitalization in advanced cases), high blood pressure, and edema (fluid buildup) caused by cirrhosis, nephrotic syndrome, or heart failure. It is also used to diagnose and treat primary hyperaldosteronism and to help manage low potassium. Because it blocks androgens, it is also commonly prescribed off-label in dermatology and women's health.
What are the most common side effects of spironolactone?
Common effects can include dizziness, increased urination, low sodium, dehydration, breast tenderness or enlargement (gynecomastia, which is related to dose and duration), and menstrual irregularities. The most important risk is hyperkalemia, or high potassium, which is why your provider monitors your blood work. Contact your doctor if you have anything concerning.
Can spironolactone treat hormonal acne?
Spironolactone is used off-label by many dermatologists for hormonal acne, hirsutism, and PCOS in women because it has anti-androgen activity. This is not an FDA-approved use, so whether it is appropriate for you is a decision for your prescriber. We do not recommend or promote off-label use here.
Why do you need to monitor potassium levels while taking spironolactone?
Spironolactone is potassium-sparing, meaning it causes your body to hold on to potassium. Too much potassium (hyperkalemia) can be dangerous and even affect your heart. The risk is higher with kidney problems, diabetes, older age, or when combined with ACE inhibitors, ARBs, potassium supplements, or salt substitutes. Regular blood tests let your provider catch and manage this early.
How long does it take for spironolactone to work?
It depends on what it is being used for. Its effect on fluid and blood pressure can begin within days, though the full effect may take a few weeks. When used for skin or hormonal concerns, people often need several weeks to a few months to notice a difference. Keep taking it as prescribed and follow up with your provider.
How much does Spironolactone cost without insurance?
The price of Spironolactone without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 73% off retail prices with a free Rx.com coupon.
What are the common side effects of Spironolactone?
Common side effects of Spironolactone may include: Confusion, uneven heartbeat, trouble breathing, numbness or tingling in your hands, feet, or lips, Lightheadedness, dizziness, drowsiness, fainting, Dry mouth, increased thirst, muscle cramps, nausea, vomiting, Blistering, peeling, red skin rash, Muscle twitching. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Spironolactone?
Generic versions may be available for Spironolactone. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Spironolactone on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Spironolactone?
The cheapest pharmacy for Spironolactone depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Spironolactone near you.

Spironolactone Coupons & Prices

Spironolactone 25MG

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Spironolactone Tablet — prescription drug image
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Looking for a spironolactone coupon? Spironolactone is a widely used generic prescription, so it is already one of the lower-cost options in its class, but the cash price can vary a lot from one pharmacy to the next. With Rx.com you can compare spironolactone prices across more than 60,000 pharmacies and get a free discount coupon to show your pharmacist. Enter your ZIP above to see today's price near you.

What is spironolactone and how does it work?

Spironolactone (sold under the brand names Aldactone and Carospir) is a potassium-sparing diuretic, also called an aldosterone receptor antagonist or mineralocorticoid receptor antagonist. It blocks the hormone aldosterone, which helps your body remove extra fluid and sodium while holding on to potassium. This lowers blood pressure and reduces swelling without wasting potassium the way many other water pills do.

It is FDA-approved to help treat heart failure (NYHA class III-IV, as add-on therapy to reduce the risk of death and hospitalization), high blood pressure, and edema (fluid buildup) from cirrhosis, nephrotic syndrome, or heart failure. It is also used to diagnose and treat primary hyperaldosteronism and to help manage low potassium (hypokalemia). Because it also has anti-androgen activity, spironolactone is very commonly prescribed off-label in dermatology and women's health.

Spironolactone cost and savings without insurance

Spironolactone is available as an FDA-approved generic, which is why it is typically an affordable medication. Even so, the cash price is not the same everywhere. Two pharmacies on the same street can list very different prices for the exact same prescription, so comparing before you fill genuinely matters. There is no manufacturer copay savings card for spironolactone because it is a low-cost generic.

If you are paying without insurance, or your plan does not cover it well, a free Rx.com discount coupon may bring the cash price down. Rx.com compares spironolactone prices across more than 60,000 U.S. pharmacies so you can find a lower price near you. Enter your ZIP above to see today's price and print or text yourself the coupon to show your pharmacist. The brand versions, Aldactone and Carospir, generally cost more than the generic.

Spironolactone alternatives and related diuretics

Spironolactone is one of several water pills, and the right choice depends on your condition and how your body handles potassium. Only your prescriber can decide what fits you, but these related medicines are often discussed alongside it:

  • Eplerenone - another aldosterone receptor antagonist, often chosen when spironolactone's hormonal side effects are a concern (note: spironolactone and eplerenone should not be combined).
  • Amiloride and Triamterene - other potassium-sparing diuretics.
  • Hydrochlorothiazide - a thiazide diuretic commonly used for high blood pressure.
  • Furosemide - a stronger loop diuretic used for more significant fluid retention.

All of these are available as generics. You can compare prices for each on Rx.com to see which is most affordable at your pharmacy.

Safety, side effects, and important warnings

Spironolactone carries a boxed warning because it was shown to cause tumors in chronic rat toxicity studies; it should not be used unnecessarily. The main safety concern is hyperkalemia (high potassium), which can be serious or even life-threatening. The risk is higher if you have kidney problems, diabetes, are older, or take ACE inhibitors, ARBs, potassium supplements, or salt substitutes. Your provider will usually check your potassium and kidney function while you take it, and you should avoid potassium-rich salt substitutes.

Other possible effects include low sodium, dehydration, dizziness, breast tenderness or enlargement (gynecomastia, related to dose and how long you take it), and menstrual changes. Spironolactone should not be used if you have high potassium, Addison's disease, no urine output (anuria), significant kidney impairment, or if you take eplerenone, and it should be avoided in pregnancy. This is general information, not medical advice; talk with your doctor or pharmacist about your own situation and any medicines you take.

Sources & accuracy

This Spironolactone information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Spironolactone on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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