What is Vonjo ?

Vonjo (pacritinib) is a prescription medication specifically designed to treat adults with certain types of myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis, and post-essential thrombocythemia myelofibrosis. It functions as a kinase inhibitor, working by blocking specific enzymes to help reduce spleen size, alleviate symptoms, and improve blood counts. Consult a healthcare provider for more detailed information and potential side effects.

• Fainting, dizziness, lightheadedness
• Rapid weight gain, swelling in your hands, ankles, or feet
• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Sudden or severe headache, problems with vision, speech, or walking
• Diarrhea
• Unusual bleeding, bruising, or weakness
• Chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, nausea, unusual sweating, fainting
• Fast, pounding, or uneven heartbeat
• Fever, chills, cough, night sweats, sore throat, body aches
• Coughing up blood, numbness or weakness in your arm or leg, or on one side of your body, pain in your lower leg
• Sores, reddish patch or irritated area, shiny bump, or pink growth on the skin
• Clumsiness, weakness on one side of your body, trouble speaking, trouble seeing, confusion

• Talk with your doctor before using this medicine if you plan to have children. Some men who use this medicine have become infertile (unable to have children).
• This medicine may cause the following problems:Serious bleeding problemsHeart rhythm problems, including QT prolongationIncreased risk of serious heart or blood vessel disease, including heart attack or strokeIncreased risk of blood clots, including deep vein thrombosis, pulmonary embolism, arterial thrombosisIncreased risk of cancer (including lymphoma, skin cancer)Increased risk of serious infections (bacterial, fungal, viral)
• Do not breastfeed during treatment and for 2 weeks after the last dose.
• Oral routeYou may also receive medicines to help prevent nausea and vomiting.
• Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine 7 days before having surgery or medical tests.
• Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
• This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
• Keep all medicine out of the reach of children. Never share your medicine with anyone.
• This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
• Tell your doctor if you are pregnant, or if you have kidney disease, liver disease, any type of infection, heart or blood vessel disease, diarrhea, active bleeding, or a history of cancer. Tell your doctor if you are a current or past smoker.