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Cresemba Capsule — prescription drug image

Cresemba

Cresemba 186MG

What is Cresemba?

Cresemba (isavuconazonium sulfate) is an antifungal medication used to treat invasive aspergillosis and mucormycosis, serious infections caused by certain types of fungi. This drug works by inhibiting the growth of fungi, thereby reducing the spread of infection, and is typically reserved for use in adults with compromised immune systems or conditions that make them more susceptible to these infections.

Prescription savings · · · ·

What is Cresemba ?

Cresemba (isavuconazonium sulfate) is an antifungal medication used to treat invasive aspergillosis and mucormycosis, serious infections caused by certain types of fungi. This drug works by inhibiting the growth of fungi, thereby reducing the spread of infection, and is typically reserved for use in adults with compromised immune systems or conditions that make them more susceptible to these infections.
  • Lightheadedness, dizziness, fainting
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Chills, dizziness, trouble breathing
  • Dry mouth, increased thirst, muscle cramps, uneven heartbeat
  • Decrease in how much or how often you urinate, difficult or painful urination
  • Numbness or tingling, change in sense of touch
  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Use effective birth control during treatment and for at least 28 days after the last dose.
  • Tell your doctor if you are breastfeeding, or if you have liver disease or heart rhythm problems (including familial short QT syndrome). Tell your doctor if you had an allergic reaction to similar medicines (including itraconazole, ketoconazole, voriconazole).
  • This medicine may cause the following problems:Liver problemsInfusion-related reactionsSerious skin reactions, including Stevens-Johnson syndrome
  • This medicine may cause liver problems.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Dry mouth, increased thirst, muscle cramps, uneven heartbeat
  • Lightheadedness, dizziness, or fainting
  • Numbness or tingling, change in sense of touch
What is Cresemba used to treat?
Cresemba (isavuconazonium sulfate) is FDA-approved to treat invasive aspergillosis and invasive mucormycosis in adults 18 years and older. These are serious fungal infections that usually affect people with weakened immune systems. It comes as oral capsules and as an IV injection. Doctors sometimes also use it off-label to prevent or treat other invasive fungal infections in immunocompromised patients, always under a prescriber's direction.
Is there a generic version of Cresemba available?
No. There is currently no generic version of Cresemba available, so the brand-name price is what you will typically pay. Because there is no generic, comparing cash prices with a discount coupon and checking manufacturer assistance options can be especially helpful for lowering your cost.
How much does Cresemba cost and is there a savings card?
Cresemba's price varies by pharmacy, dose, and whether you use the oral or IV form, so enter your ZIP code above to see today's cash price near you with the Rx.com coupon. The maker, Astellas, offers a manufacturer savings card at activatethecard.com/cresemba, but manufacturer cards are generally limited to people with commercial insurance and cannot be used with Medicare or Medicaid. If you are uninsured, on Medicare, or the card is declined, an Rx.com cash coupon is an alternative. Manufacturer terms can change, so check the official page for details.
What are the most common side effects of Cresemba?
The most common side effects include nausea, vomiting, diarrhea, headache, elevated liver tests, low potassium, constipation, and swelling in the arms or legs. Cresemba can also affect the liver, so your provider may monitor your liver function. This is not a complete list. Contact your provider about any side effects or concerns.
Can you take Cresemba while pregnant?
No, Cresemba should generally be avoided during pregnancy because it can cause harm to an unborn baby. People who can become pregnant are advised to use effective contraception while taking it. If you are pregnant, planning a pregnancy, or breastfeeding, talk with your provider before using Cresemba so you can weigh the risks and benefits together.
How much does Cresemba cost without insurance?
The price of Cresemba without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Cresemba?
Common side effects of Cresemba may include: Lightheadedness, dizziness, fainting, Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Blistering, peeling, red skin rash, Chills, dizziness, trouble breathing. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Cresemba?
Generic versions may be available for Cresemba. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Cresemba on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Cresemba?
The cheapest pharmacy for Cresemba depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Cresemba near you.

Cresemba Coupons & Prices

Cresemba 186MG

Cresemba Capsule — prescription drug image
Prescription
Cresemba 186mg (2)
your area ·

Looking for a Cresemba coupon? Cresemba (isavuconazonium sulfate) is a brand-name triazole antifungal used to treat serious, invasive fungal infections, and because there is no generic version, the price can be high. On this page you can enter your ZIP code above to see today's cash price at pharmacies near you and use the Rx.com discount coupon, which can help whether you are uninsured, on Medicare, or paying out of pocket. Below we explain what Cresemba is, how the manufacturer savings card compares with an Rx.com cash coupon, and how it stacks up against related antifungal medicines.

What is Cresemba and how does it work?

Cresemba is the brand name for isavuconazonium sulfate, a prodrug that the body converts into isavuconazole, an azole (triazole) antifungal. It is FDA-approved to treat invasive aspergillosis and invasive mucormycosis in adults 18 years and older. These are serious fungal infections that most often affect people with weakened immune systems. Cresemba comes as oral capsules and as an intravenous (IV) injection given in a healthcare setting.

Azole antifungals like isavuconazole work by blocking the fungus from making ergosterol, a key building block of its cell membrane, which stops the fungus from growing. Doctors sometimes also use Cresemba off-label to help prevent or treat other invasive fungal infections in immunocompromised patients, such as those with blood cancers or who have had a transplant. Any use should be directed and monitored by your prescriber.

Cresemba cost: manufacturer savings card vs. Rx.com cash coupon

There is no generic version of Cresemba available yet, so the brand-name price is what you will typically see. Astellas, the maker of Cresemba, offers a manufacturer savings card through its official site at activatethecard.com/cresemba. Manufacturer copay cards like this are generally limited to people with commercial (private) insurance and cannot be used if you have Medicare, Medicaid, or other government coverage. Terms, eligibility, and any savings limits are set by the manufacturer and can change, so check the official page for current details.

If you are uninsured, covered by Medicare, or the manufacturer card is declined at the pharmacy, an Rx.com cash coupon is a helpful alternative. It is a discount coupon that anyone can use instead of insurance. To compare, enter your ZIP above to see today's cash price with the Rx.com coupon at pharmacies near you. Astellas also runs patient support programs; you can learn about access and assistance options through the manufacturer's access and support resources.

Cresemba alternatives and related antifungals

Cresemba is one of several azole antifungals used for invasive fungal infections. The best choice depends on the specific infection, other medicines you take, and your prescriber's judgment. Related medicines you may see or want to price-compare include:

Several of these are available as generics, which is often the biggest lever for lowering cost. Do not switch antifungals on your own, as they differ in what infections they treat and how they interact with other drugs. Talk with your provider about the right option for you.

Cresemba safety and side effects

Cresemba does not carry a boxed warning, but there are important safety points to know. It can affect the liver, so your provider may check your liver function, and it is used with caution in people with liver problems. It can cause harm to an unborn baby, so it should be avoided in pregnancy and effective contraception is advised. It should not be used by people with a known hypersensitivity to azole antifungals, and infusion-related reactions can occur with the IV form. Cresemba has important drug interactions through a liver enzyme called CYP3A4 and should not be combined with strong CYP3A4 inhibitors (such as ketoconazole) or strong inducers (such as rifampin, carbamazepine, or St. John's wort). It is also contraindicated in people with familial short QT syndrome.

Common side effects include nausea, vomiting, diarrhea, headache, elevated liver tests, low potassium (hypokalemia), constipation, and swelling in the arms or legs (peripheral edema). This is not a complete list and is not medical advice. Tell your provider about all medicines you take and any reactions you notice, and follow their guidance.

Sources & accuracy

This Cresemba information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Cresemba on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.