Esomeprazole Sodium Coupons & Prices

If you're comparing prices for an esomeprazole sodium coupon, keep in mind this is the injectable (IV) form of esomeprazole — a proton pump inhibitor typically given by a healthcare professional in a hospital or clinical setting rather than picked up as a take-home prescription. A generic version is available from multiple manufacturers, but injectable-drug pricing can still vary by pharmacy and supplier. Enter your ZIP code above and Rx.com compares pricing across more than 60,000 U.S. pharmacies so you can see today's price before you fill.

What Is Esomeprazole Sodium?

Esomeprazole sodium is the injectable (IV) form of esomeprazole, the S-isomer of omeprazole, in the proton pump inhibitor (PPI) drug class. It's formulated as a sodium salt supplied as a powder that a healthcare professional reconstitutes and administers by IV infusion or injection. Like other PPIs, it works by blocking the stomach's acid-producing pumps, reducing the amount of acid the stomach makes.

The product was originally introduced by AstraZeneca under the brand name Nexium I.V. Today it's supplied almost entirely as generic esomeprazole sodium for injection, including versions from manufacturers such as Gland Pharma and Eugia US.

Esomeprazole Sodium Cost and Savings

Esomeprazole sodium for injection is available as a generic, supplied by multiple manufacturers rather than under one dominant brand. Because it's most often given by a healthcare professional during a hospital stay or an outpatient infusion visit, the cost is typically billed through that facility and your insurance rather than picked up like a retail prescription. If you or a caregiver do need to price or fill an outpatient order, cost can still vary by pharmacy and supplier, so it pays to compare.

Enter your ZIP code above to compare pricing across pharmacies in the Rx.com network. Rx.com does not have a manufacturer savings card on file for esomeprazole sodium injection.

Esomeprazole Sodium vs. Oral Esomeprazole, Nexium, and Other PPIs

Esomeprazole sodium injection and oral esomeprazole (the generic of Nexium) deliver the same active PPI molecule, but they are different salts, given by different routes, for different FDA-approved uses. The oral tablet/capsule form is used for a broader range of conditions, including GERD, erosive esophagitis healing and maintenance, and — combined with antibiotics — H. pylori eradication. The injectable sodium form is reserved for short-term IV use when oral therapy isn't possible or appropriate, and for reducing rebleeding risk in adults after endoscopic treatment of a bleeding gastric or duodenal ulcer.

Other medicines in the same PPI class include omeprazole, pantoprazole, and lansoprazole. All work by reducing stomach acid production, though route of administration, approved patient ages, and specific indications differ — ask your care team which option fits your situation.

Safety Information

Esomeprazole sodium injection does not carry an FDA boxed warning. The current injection label includes warnings about acute kidney inflammation (acute tubulointerstitial nephritis) that can occur at any point during treatment, an increased risk of Clostridioides difficile-associated diarrhea, bone fracture risk with long-term or high-dose use, severe cutaneous adverse reactions, cutaneous and systemic lupus erythematosus, low magnesium levels (hypomagnesemia) with prolonged use, reduced effectiveness of clopidogrel when taken together, an interaction with St. John's Wort or rifampin that can lower esomeprazole levels, interference with diagnostic tests for neuroendocrine tumors, an interaction with high-dose methotrexate, and stomach (fundic gland) polyps with long-term use. It can also mask symptoms of stomach cancer, so tell your care team about any concerning symptoms before starting treatment.

• Headache
• Flatulence
• Nausea
• Abdominal pain
• Injection site reaction
• Diarrhea
• Dry mouth
• Dizziness or vertigo
• Constipation
• Itching (pruritus)

This is general information, not medical advice. Talk to your doctor, nurse, or pharmacist about your specific treatment plan and any interactions with your other medications.