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Methadose Bottle — prescription drug image

Methadose

Methadose 1000ML of 10MG/ML

What is Methadose?

Methadose is an opioid medication used as a pain reliever. There is currently no generic version of Methadose available in the United States. The average cost for 1000 ml, 10 mg/mL Methadose oral concentrate is about $99. Use our free Rx.com coupon card and get up to 80% off your Banzel prescription at any participating pharmacy.

Prescription savings · · · ·

What is Methadose ?

Methadose is an opioid medication used as a pain reliever. There is currently no generic version of Methadose available in the United States. The average cost for 1000 ml, 10 mg/mL Methadose oral concentrate is about $99. Use our free Rx.com coupon card and get up to 80% off your Banzel prescription at any participating pharmacy.
  • Severe constipation, stomach pain, nausea, vomiting
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Anxiety, confusion, restlessness, fever, muscle spasms, twitching, diarrhea, seeing or hearing things that are not there
  • Lightheadedness, dizziness, fainting
  • Changes in skin color, dark freckles, cold feeling, tiredness, weight loss
  • Fast, pounding, or uneven heartbeat
  • Blue lips, fingernails, or skin, trouble breathing
  • Extreme dizziness or weakness, shallow breathing, slow or uneven heartbeat, sweating, seizures, cold or clammy skin
  • Shaking, trembling, sweating, hunger
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, diabetes, heart disease, heart rhythm problems (including long QT syndrome), adrenal problems, breathing or lung problems (including asthma, COPD, sleep apnea), gallbladder problems, low magnesium or potassium in the blood, pancreas problems, stomach or bowel problems, or trouble urinating. Tell your doctor if you have a history of head injury, brain tumor, seizures, depression, or alcohol or drug addiction.
  • This medicine may cause the following problems:High risk of overdose, which can lead to deathRespiratory depression (serious breathing problem that can be life-threatening)Sleep-related breathing problems (including sleep apnea, sleep-related hypoxemia)Adrenal gland problemsHeart rhythm problemsLow blood pressureSerotonin syndrome, when used with certain medicinesSeizuresLow blood sugar
  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • This medicine may make you dizzy, drowsy, or lightheaded. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.
  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation. Drink plenty of liquids to help avoid constipation.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
What is Methadose used for?
Methadose is a brand of methadone hydrochloride oral concentrate. It is FDA-approved only for the detoxification and maintenance treatment of opioid addiction, and it is dispensed solely through SAMHSA-certified opioid treatment programs. Methadose oral concentrate is not approved for pain; the pain indication belongs to methadone tablets, a different product.
Is Methadose the same as methadone?
Yes. Methadose is a brand name for methadone hydrochloride, the same active ingredient. The Methadose oral concentrate is 10 mg/mL and also comes in a sugar-free version. Substitutable generic methadone is available and is usually the lower-cost option for a retail prescription.
How long does Methadose stay in your system?
Methadone is long-acting and has a long, variable half-life, so it can remain in the body and be detectable for several days after a dose. Because it can build up over time, only a clinician experienced with methadone should adjust the dose. Your provider can give guidance specific to you.
What are the most dangerous side effects of methadone?
The most serious risks appear in the FDA boxed warnings for Methadose oral concentrate: life-threatening slowed or stopped breathing (respiratory depression); QT-interval prolongation and a dangerous heart rhythm called torsades de pointes; accidental ingestion that can be fatal, especially in children; the abuse potential of this Schedule II opioid; and fatal overdoses tied to interactions with drugs that affect CYP450 liver enzymes. Combining methadone with benzodiazepines, alcohol, or other CNS depressants is also very dangerous. Seek emergency help for very slow breathing, extreme drowsiness, or fainting.
Why is Methadose only dispensed at opioid treatment programs?
When methadone is used to treat opioid addiction, federal rules require that it be dispensed through SAMHSA-certified opioid treatment programs. This structured setting allows for supervised dosing, monitoring, and counseling because of methadone's overdose and heart-rhythm risks. Methadone tablets prescribed for pain, by contrast, can be filled at a retail pharmacy.
How much does Methadose cost without insurance?
The price of Methadose without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 96% off retail prices with a free Rx.com coupon.
What are the common side effects of Methadose?
Common side effects of Methadose may include: Severe constipation, stomach pain, nausea, vomiting, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Anxiety, confusion, restlessness, fever, muscle spasms, twitching, diarrhea, seeing or hearing things that are not there, Lightheadedness, dizziness, fainting, Changes in skin color, dark freckles, cold feeling, tiredness, weight loss. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Methadose?
Generic versions may be available for Methadose. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Methadose on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Methadose?
The cheapest pharmacy for Methadose depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Methadose near you.

Methadose Coupons & Prices

Methadose 1000ML of 10MG/ML

Methadose Bottle — prescription drug image
Prescription
Methadose 1000ml of 10mg/ml (0.02)
your area ·

Looking for a Methadose coupon? Methadose is a brand of methadone hydrochloride oral concentrate, a long-acting opioid used for the detoxification and maintenance treatment of opioid use disorder. Because Methadose is dispensed only through federally certified opioid treatment programs, it is not a medicine you pick up at a regular retail pharmacy, so a standard pharmacy coupon usually does not apply to Methadose itself. Generic methadone is available, and it is methadone tablets prescribed for pain and filled at a retail pharmacy where an Rx.com cash coupon can lower what you pay. Enter your ZIP above to see today's price at pharmacies near you.

What is Methadose and how does it work?

Methadose is a brand name for methadone hydrochloride oral concentrate, a synthetic long-acting opioid that works as a mu-opioid receptor agonist. Methadose oral concentrate is supplied at 10 mg/mL, and a sugar-free version is also made. It is FDA-approved for one purpose: the detoxification and maintenance treatment of opioid addiction, and under federal rules it is dispensed only through SAMHSA-certified opioid treatment programs. Methadose oral concentrate is not approved for pain. The management of severe, around-the-clock pain is an indication of methadone tablets (such as Dolophine and its generics), which are a different product from the Methadose concentrate.

Because methadone acts on the same receptors as other opioids but lasts much longer, it can ease withdrawal and cravings in addiction treatment. Its long and variable half-life means the drug can build up in the body over days, so only clinicians experienced with methadone should start and adjust the dose. This is general information, not medical advice; talk with your provider or treatment program about what is right for you.

Methadose cost and savings: is there a coupon?

Methadose does not have a manufacturer copay or savings card, so there is no brand savings program to enroll in. It is also dispensed through a certified opioid treatment program rather than a regular pharmacy, and many programs bill insurance, Medicaid, or offer their own pricing, so a retail cash coupon usually does not apply to Methadose oral concentrate.

Where an Rx.com cash coupon can help is with generic methadone tablets prescribed for pain and filled at a retail pharmacy. An FDA-approved, substitutable generic methadone is available, and asking your prescriber and pharmacist about it often lowers the cost of a retail prescription. A cash coupon is useful if you are uninsured, if you have Medicare, or if your insurance is declined at the counter. It is not insurance, and you use whichever price is lower. Enter your ZIP above to see today's price at pharmacies near you.

Methadose vs. other options for opioid use disorder

Methadone is one of several FDA-approved medicines used in opioid use disorder, and the right choice depends on your history and your care team. Others your provider may discuss include:

  • buprenorphine and the combination product Suboxone (buprenorphine and naloxone), which can be prescribed in office-based settings
  • naltrexone, an opioid blocker used after detox to help prevent relapse
  • generic methadone, the same active ingredient as Methadose in a lower-cost form

These medicines work in different ways, and only a qualified clinician or treatment program can decide which is appropriate. This is educational information, not a recommendation to start, stop, or switch any medication.

Important safety information

Methadose oral concentrate carries several FDA boxed warnings specific to this product. These include life-threatening respiratory depression, especially when starting the drug or increasing the dose; QT-interval prolongation and a serious heart rhythm problem called torsades de pointes, which is why ECG monitoring may be advised; accidental ingestion, which can cause fatal overdose, especially in a child; the abuse potential of methadone as a Schedule II opioid; and dangerous interactions with medicines that affect CYP450 liver enzymes, which can lead to fatal overdose. A further boxed warning covers the federal conditions required to distribute methadone through certified opioid treatment programs. Combining methadone with benzodiazepines, alcohol, or other central nervous system depressants can also cause profound sedation, slowed breathing, coma, and death.

Methadone's complex, variable pharmacokinetics and long half-life create a real risk of the drug accumulating in the body, so doses should be titrated only by clinicians familiar with it. Because accidental ingestion can be fatal, store it securely and away from children. This is not a complete list of risks and is not medical advice; report worrying symptoms and questions to your provider or treatment program right away.

Sources & accuracy

This Methadose information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Methadose on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.