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Proglycem Bottle — prescription drug image

Proglycem

Proglycem 30ML of 50MG/ML

What is Proglycem?

Proglycem, with the generic name diazoxide, is an oral medication primarily used to treat hypoglycemia (low blood sugar) associated with conditions such as hyperinsulinism. It functions by inhibiting the release of insulin from the pancreas, thus helping to stabilize blood sugar levels. Typically prescribed when dietary changes or other treatments are insufficient, Proglycem plays a critical role in managing insulin-related disorders to prevent hypoglycemic episodes.

Prescription savings · · · ·

What is Proglycem ?

Proglycem, with the generic name diazoxide, is an oral medication primarily used to treat hypoglycemia (low blood sugar) associated with conditions such as hyperinsulinism. It functions by inhibiting the release of insulin from the pancreas, thus helping to stabilize blood sugar levels. Typically prescribed when dietary changes or other treatments are insufficient, Proglycem plays a critical role in managing insulin-related disorders to prevent hypoglycemic episodes.
  • Lightheadedness, dizziness, or fainting
  • Rapid weight gain, swelling in your hands, ankles, or feet, trouble breathing, tiredness
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Fast, pounding, or uneven heartbeat
  • Increased hunger or thirst, increase in how much or how often you urinate
  • Trouble breathing, especially in a child
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, heart failure, edema, lung or breathing problems, or a history of gout.
  • This medicine may cause ketoacidosis (high levels of ketones in the blood) or severe high blood sugar levels and dehydration, which could lead to coma. You will need to test yourself for ketones and sugar levels.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Trouble breathing, especially in a child
What is Proglycem (diazoxide) used for?
Proglycem (diazoxide) oral suspension is used to manage symptomatic low blood sugar caused by hyperinsulinism—conditions in which the pancreas releases too much insulin, such as islet cell tumors, islet cell hyperplasia, nesidioblastosis, certain cancers outside the pancreas, or leucine-sensitive hypoglycemia. It's used in adults with insulinoma-type hyperinsulinism and in infants and neonates with congenital hyperinsulinism. It works by suppressing insulin release from the pancreas and is not used for functional (reactive) hypoglycemia that occurs after eating.
Is there a generic version of Proglycem, and is it cheaper?
Yes, diazoxide oral suspension is available generically. Because it has the same active ingredient, strength, and form as brand-name Proglycem, a pharmacist can typically substitute it. Pricing for both versions varies by pharmacy and insurance, so it's worth comparing—enter your ZIP above to see today's price at pharmacies near you.
What are the main side effects of Proglycem?
Beyond its FDA warning about pulmonary hypertension in infants, Proglycem commonly causes fluid and sodium retention, which can worsen or trigger heart failure and is often managed by giving it alongside a diuretic. It can also raise blood sugar, potentially leading to hyperglycemia, ketoacidosis, or nonketotic hyperosmolar coma, especially during another illness, so glucose monitoring is important. With longer-term use, hypertrichosis (excess hair growth) is common; edema, GI upset, and rare blood-cell effects can also occur. Talk with your provider about what monitoring you'll need.
Why does Proglycem carry a pulmonary hypertension warning for infants?
The FDA warning exists because pulmonary hypertension has been reported in neonates and infants treated with diazoxide, particularly those with risk factors like prematurity, meconium aspiration, sepsis, or existing congenital heart or diaphragmatic disease. Because of this, infants on Proglycem need to be monitored for signs of respiratory distress, and the drug should be stopped if pulmonary hypertension is suspected—the condition is often reversible once treatment ends.
How much does Proglycem cost without insurance?
The cash price for Proglycem, and for generic diazoxide, varies by pharmacy and location and can change frequently. Rather than quote a number that may be out of date, enter your ZIP code above to see current pricing at pharmacies near you, including where a coupon may lower the price further.
How much does Proglycem cost without insurance?
The price of Proglycem without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Proglycem?
Common side effects of Proglycem may include: Lightheadedness, dizziness, or fainting, Rapid weight gain, swelling in your hands, ankles, or feet, trouble breathing, tiredness, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Fast, pounding, or uneven heartbeat, Increased hunger or thirst, increase in how much or how often you urinate. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Proglycem?
Generic versions may be available for Proglycem. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Proglycem on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Proglycem?
The cheapest pharmacy for Proglycem depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Proglycem near you.

Proglycem Coupons & Prices

Proglycem 30ML of 50MG/ML

Proglycem Bottle — prescription drug image
Prescription
Proglycem 30ml of 50mg/ml (0.2)
your area ·

Proglycem prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
30ml of 50mg/ml · Bottle 30 $609.19 $525.63

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

If you or a family member has been prescribed Proglycem (diazoxide) oral suspension for hyperinsulinism-related low blood sugar, a Proglycem coupon can make the cash price more manageable—especially since diazoxide is also available as a generic. Enter your ZIP code above to compare pharmacy prices for Proglycem and generic diazoxide near you, whether you're uninsured, on Medicare, or paying cash.

What Is Proglycem (Diazoxide) and How Does It Work?

Proglycem is the brand name for diazoxide oral suspension, a nondiuretic benzothiadiazine that works as an antihypoglycemic agent by suppressing insulin release from the pancreas. It's FDA-approved to manage symptomatic hypoglycemia caused by hyperinsulinism. In adults, it's indicated for inoperable islet cell adenoma or carcinoma, or extrapancreatic malignancy. In infants and children, it's indicated for leucine sensitivity, islet cell hyperplasia, nesidioblastosis, extrapancreatic malignancy, islet cell adenoma, or adenomatosis.

Proglycem is used in adults with insulinoma-type hyperinsulinism as well as in infants and neonates with congenital hyperinsulinism (persistent hyperinsulinemic hypoglycemia of infancy). It is not appropriate for functional (reactive) hypoglycemia, the type of low blood sugar that can occur after eating—Proglycem is contraindicated for that use.

Proglycem Coupon: Generic Diazoxide and the Rx.com Cash Price

Diazoxide oral suspension is available as a generic, so the biggest way to lower your out-of-pocket cost is usually filling the generic rather than brand-name Proglycem—ask your pharmacist whether a substitution is appropriate for your prescription. Pricing for both the brand and the generic varies by pharmacy and can change often, so it's worth comparing before you fill.

A Proglycem coupon from Rx.com can be used at participating pharmacies regardless of your insurance status—whether you're uninsured, on Medicare (which typically doesn't cover cash-discount coupons alongside a Part D plan, but can use one instead of insurance when it's cheaper), or simply comparing your options. Enter your ZIP above to see today's price for Proglycem and generic diazoxide at pharmacies near you.

Related Treatments for Hyperinsulinism and Severe Hypoglycemia

Because Proglycem and generic diazoxide share the same active ingredient, dose, and form, they can typically be substituted for one another at the pharmacy. Other medications are sometimes used for related conditions: octreotide is a somatostatin analog occasionally used to manage certain hyperinsulinism cases, while glucagon is used for emergency treatment of severe hypoglycemia itself rather than for ongoing insulin suppression.

These are different drugs for related but distinct clinical situations—talk with your endocrinologist or prescriber about which treatment fits your specific diagnosis before switching anything.

Safety Information: Warnings and Key Precautions

Proglycem carries an FDA safety warning: pulmonary hypertension has been reported in neonates and infants treated with diazoxide, particularly those with risk factors such as prematurity, meconium aspiration, sepsis, or existing congenital heart or diaphragmatic disease. These infants should be monitored for signs of respiratory distress, and the drug should be discontinued if pulmonary hypertension is suspected—the condition is often reversible once diazoxide is stopped.

Proglycem also causes fluid and sodium retention, which can trigger or worsen heart failure and is why it's often given together with a diuretic. It can raise blood glucose to the point of hyperglycemia, ketoacidosis, or nonketotic hyperosmolar coma—especially during another illness—so regular glucose monitoring is required. With prolonged use, hypertrichosis (excess hair growth) is common; edema, GI upset, and rare blood-cell effects have also been reported. This is general information, not medical advice—work with your prescriber on a monitoring plan that fits your situation.

Sources & accuracy

This Proglycem information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Proglycem on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.