Promethazine Hcl Coupons & Prices

A promethazine HCl coupon from Rx.com lets you compare the cash price of generic promethazine hydrochloride across more than 60,000 U.S. pharmacies before you fill it. Promethazine is a first-generation antihistamine used for allergy symptoms, for nausea and vomiting related to certain surgery and anesthesia, for motion sickness, and for sedation. The generic is widely available and substitutable, but what a pharmacy charges you in cash can differ a lot from one store to the next, even within the same town. Enter your ZIP above to see today's price near you and bring the coupon to the counter.

What is promethazine HCl and how does it work?

Promethazine hydrochloride is a phenothiazine derivative that acts as an H1 antihistamine. Along with blocking histamine, it has antiemetic (anti-nausea), sedative and anticholinergic activity, and it also blocks dopamine D2 receptors. Unlike other phenothiazines, promethazine is not used as an antipsychotic. The brand Phenergan tablets were discontinued in the U.S., so what pharmacies dispense today is the generic. Related products under other names include Phenadoz and Promethegan suppositories, and combination products such as promethazine VC and promethazine with codeine.

On the oral and rectal labels, FDA-approved uses include perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis, allergic reactions to blood or plasma, uncomplicated allergic skin reactions such as hives and angioedema, dermographism, adjunctive therapy with epinephrine in anaphylaxis, and easing allergic reactions to drugs. It is also approved for prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery, for motion sickness, for preoperative, postoperative and obstetric sedation, as an adjunct to pain relievers after surgery, and for sedation and relief of apprehension. Your prescriber decides which of these applies to you.

What promethazine costs without insurance, and why comparing matters

Promethazine HCl is a generic with no manufacturer savings card, so a discount coupon is the main way most cash-paying patients lower the price. There is no single national price. Pharmacies set their own cash prices, and the spread between a grocery-store pharmacy, a big chain and an independent down the street can be wide for the exact same tablets and quantity. That is why it pays to check before you fill rather than after.

Rx.com compares cash prices at more than 60,000 pharmacies and shows the discounted price you would pay at each one. The coupon is free and does not require insurance. If you do have insurance, it is worth comparing your copay against the cash coupon price, because for inexpensive generics the coupon is sometimes the better of the two. Enter your ZIP above to see today's price near you.

Promethazine alternatives and how it compares

Promethazine is one of several options a prescriber may consider, and the right one depends on what is being treated. For nausea and vomiting, other commonly prescribed medicines include ondansetron (brand Zofran), prochlorperazine and metoclopramide. For motion sickness, meclizine is a frequent alternative and is far less sedating for many people. For allergy symptoms, other antihistamines such as hydroxyzine HCl and diphenhydramine are used.

Within the promethazine family, promethazine DM and promethazine with codeine are separate combination products with their own labels and their own prices. Because these medicines differ in how sedating they are and in their side effects, the choice is one to make with your prescriber, not on price alone. Once you know which one you are filling, compare the cash price for that exact product and quantity.

Safety information worth knowing

The oral and rectal forms of promethazine carry a boxed warning: it is contraindicated in children under 2 years of age because of the potential for fatal respiratory depression. In children 2 and older, the lowest effective dose should be used, with caution if other medicines that depress breathing are also being taken. The injection carries a separate boxed warning about severe tissue injury, including gangrene. Promethazine should not be used in comatose states, in anyone with hypersensitivity to promethazine or other phenothiazines, or to treat lower respiratory tract symptoms including asthma.

Promethazine causes marked drowsiness that can impair driving or operating machinery, and its effects add to those of alcohol, opioids, sedatives and other CNS depressants. Other label warnings include a lowered seizure threshold, neuroleptic malignant syndrome, bone marrow depression including leukopenia and agranulocytosis, extrapyramidal and dystonic reactions, cholestatic jaundice and photosensitivity. Anticholinergic effects such as dry mouth, blurred vision and urinary retention mean it should be avoided in narrow-angle glaucoma, prostatic hypertrophy, bladder-neck obstruction and stenosing peptic ulcer. It may interfere with pregnancy tests and raise blood glucose. Older adults are more prone to confusion, heavy drowsiness and falls, and promethazine appears on the AGS Beers Criteria as potentially inappropriate for them. Some formulations contain sulfites, which can trigger asthma or anaphylaxis in susceptible people. This is a summary, not medical advice; read the label that comes with your prescription and talk with your prescriber or pharmacist about your own situation.