Zoryve Coupons & Prices

Looking for a Zoryve coupon? Zoryve (roflumilast) is a brand-name, steroid-free topical medicine from Arcutis, applied to the skin once a day. It comes as a cream (0.3%, 0.15%, and 0.05%) and as a topical foam (0.3%), and it is used for plaque psoriasis, atopic dermatitis (eczema), and seborrheic dermatitis, depending on the strength and form. There is no generic version of Zoryve in the United States right now, and cash prices for the same tube or can vary from one pharmacy to the next. Enter your ZIP code above to see today's Rx.com cash price for Zoryve at pharmacies near you, and show the free coupon at the counter. Your Rx.com coupon is not insurance, and it cannot be combined with insurance on the same fill.

What is Zoryve and how does it work?

Zoryve is topical roflumilast, a phosphodiesterase-4 (PDE4) inhibitor. PDE4 is an enzyme inside skin cells that helps drive inflammation. By blocking it, Zoryve calms the inflammation behind red, scaly, or itchy patches. It is not a corticosteroid, so it does not carry the usual steroid limits on how long you can use it or where you can put it, including thin-skin areas such as the face, groin, and skin folds. It is applied once daily to the affected skin.

The FDA-approved uses depend on the exact product:

• Zoryve cream 0.3% - plaque psoriasis, including intertriginous (skin-fold) areas, in adults and children 2 years of age and older.
• Zoryve cream 0.15% - mild to moderate atopic dermatitis (eczema) in adults and children 6 years of age and older.
• Zoryve cream 0.05% - mild to moderate atopic dermatitis in children 2 to 5 years of age.
• Zoryve topical foam 0.3% - seborrheic dermatitis in patients 9 years of age and older, and plaque psoriasis of the scalp and body in patients 12 years of age and older.

Because the strengths are approved for different conditions and different ages, the tube your prescriber writes for matters. Fill exactly what is on the prescription, and do not swap strengths on your own.

One point of confusion worth clearing up: oral roflumilast, sold as Daliresp, is a completely different product taken as a pill for COPD. Topical Zoryve is not used for COPD.

Zoryve cost, the manufacturer savings card, and the Rx.com cash coupon

Zoryve is brand-only. Because no FDA-approved generic roflumilast cream or foam is marketed in the U.S., there is no substitutable generic version to ask your pharmacist for. Cash prices for the same product can vary a lot from one pharmacy to the next, so it is worth comparing before you go. Enter your ZIP above to see today's Rx.com price at pharmacies near you.

Arcutis runs an official savings program for Zoryve (marketed as Zoryve Direct) on the manufacturer's own website. Like most brand copay cards, it is generally limited to people with commercial (non-government) insurance, and the eligibility rules, benefit amount, and expiration terms vary and change over time, so check the manufacturer's site directly for the current terms. Manufacturer cards typically exclude Medicare, Medicaid, TRICARE, and other government coverage, and they do nothing if you have no insurance at all. That is where a cash coupon fits: the free Rx.com coupon is a cash-price discount, not insurance, so it can be used if you are uninsured, if you are on Medicare or another government plan that the manufacturer card refuses, or if your pharmacy tells you the copay card was declined. If cost is still out of reach, ask the prescriber's office about manufacturer assistance options and about whether a different treatment would work for your skin condition.

Zoryve alternatives and how they compare

Zoryve's main selling point is that it is steroid-free and once daily, which makes it useful on the face, groin, and skin folds where long-term steroid use is a problem. Other options your dermatologist may discuss, depending on the condition being treated:

• Steroid-free topicals for eczema: Eucrisa (crisaborole), also a topical PDE4 inhibitor, and Elidel (pimecrolimus), a topical calcineurin inhibitor.
• Steroid-free topical for psoriasis: Vtama (tapinarof) cream.
• Topical corticosteroids: clobetasol and triamcinolone are available as generics, but they carry limits on how long they can be used and where they can be applied.
• Seborrheic dermatitis: topical antifungals such as ketoconazole are a common first step and are available as generics.
• Systemic options for more extensive disease: Otezla (apremilast), an oral PDE4 inhibitor, and Dupixent (dupilumab), an injectable biologic.

Which option is right depends on your diagnosis, where the rash is, and your medical history - that is a conversation for your prescriber, not a coupon page. If your clinician agrees that a generic topical is appropriate for you, compare cash prices for it as well, since prices vary by pharmacy.

Safety, side effects, and interactions

Zoryve has no boxed warning. It is contraindicated in people with moderate to severe liver impairment (Child-Pugh B or C). It is for use on the skin only - not for use in the eyes, mouth, or vagina - and you should avoid getting it in your eyes. The propellants in Zoryve topical foam are flammable, so avoid fire, flame, and smoking during and right after applying the foam. The most commonly reported side effects across the cream and foam include diarrhea, headache, nausea, vomiting, trouble sleeping, application-site pain, burning, or stinging, upper respiratory tract infection, and urinary tract infection. In children ages 2 to 5, the most common reports were upper respiratory infection, diarrhea, vomiting, runny nose, and conjunctivitis.

Tell your prescriber and pharmacist about every medicine you take. Strong CYP3A4 inhibitors, and drugs that block both CYP3A4 and CYP1A2 (including some oral contraceptives), can raise the amount of roflumilast in your body. Zoryve is not recommended during labor and delivery, and if you are pregnant or breastfeeding you should discuss it with a clinician first. Animal studies showed a cancer signal with oral roflumilast in hamsters, while dermal studies in mice did not show carcinogenicity. This page is general information, not medical advice - read the label that comes with your prescription and follow your provider's instructions.