GHK-Cu Renewal Cream: Clinical-Grade Copper Peptide
Firmer skin. Faster repair. A pharmacy-compounded formula that pairs the copper peptide GHK-Cu with estriol, niacinamide and hyaluronic acid. Reviewed by a licensed clinician and shipped to your door. No clinic visit required.
- Prescription-strength, not a drugstore serum
- Compounded by a certified U.S. pharmacy
- Clinician-reviewed, prescribed online
- Free 2-day temperature-controlled shipping
Monthly membership
GHK-Cu Renewal Cream
30g monthly supply. Pause or cancel anytime.
- Licensed clinician review included
- Free 2-day temperature-controlled shipping
- Automatic monthly refills
- Ongoing clinical support
What is GHK-Cu Renewal Cream?
GHK-Cu is a copper peptide your body makes naturally — and steadily loses with age. It plays a direct role in collagen production, cellular repair and calming the inflammatory signals behind dull, tired-looking skin. That decline is one reason skin gets thinner, less firm and slower to bounce back over time.
System Labs delivers GHK-Cu at a therapeutic concentration, not the trace amount found in over-the-counter serums — combined with estriol, niacinamide and hyaluronic acid in a single formula that a certified U.S. pharmacy compounds to order.
Because it is prescription strength, every order starts with a short online intake reviewed by a licensed clinician. If it's appropriate for you, the pharmacy compounds your formula and ships it in temperature-controlled packaging.
Four actives, one formula
Each ingredient plays a specific role in firmer, clearer, more resilient skin.
GHK-Cu 0.2%
The copper peptide
Supports collagen production, cellular repair and the regulation of inflammatory signals — the core of the renewal effect.
Estriol 0.3%
Skin conditioning estrogen
A gentle estrogen studied for its role in skin thickness, elasticity and hydration as estrogen levels change with age.
Niacinamide 3%
Vitamin B3
Helps improve tone and clarity, supports the skin barrier and calms redness and uneven texture.
Hyaluronic Acid 0.5%
The moisture magnet
Draws water into the skin for immediate plumping and a smoother, more hydrated surface.
Why choose a compounded formula over a drugstore serum
- Prescription-strength GHK-Cu, not a trace cosmetic dose
- Four complementary actives in one formula
- Compounded fresh by a certified U.S. pharmacy
- Reviewed and prescribed by a licensed clinician
- Temperature-controlled shipping to protect potency
- One flat monthly price with clinical support included
How it works
2-minute online intake
Answer a short set of questions about your skin and health from your phone. No appointment, no waiting room.
Clinician review
A licensed clinician reviews your information over chat and approves treatment if the formula is right for you.
Compounded & delivered
A certified pharmacy compounds your formula and ships it free with 2-day temperature-controlled delivery. Refills continue monthly and you can cancel anytime.
What to expect
Consistency matters. Applied daily, the formula works on a natural timeline. Individual results vary.
Weeks 1–3
Skin often feels more hydrated and looks smoother as hyaluronic acid and niacinamide get to work.
Weeks 4–6
Most people begin noticing improvements in skin texture and tone with consistent daily use.
Beyond 6 weeks
Changes in firmness and collagen density develop over a longer timeline of continued use.
What members say
"System Labs has been wonderful. My skin looks so much brighter and healthy."
Shelley S., 43"Quality products with medical supervision. I've noticed a real difference."
Peter J., 39"I'm really noticing a difference in my skin. I'm 68 and feeling better than I have in years."
Kathryn B., 68Important safety information
GHK-Cu Renewal Cream is a compounded prescription product containing estriol, a hormone. Tell the clinician about your full medical history during the intake — including any history of hormone-sensitive conditions, pregnancy or breastfeeding, or medications you take — so they can decide whether the formula is appropriate for you.
This product is applied to the skin, not injected. Discontinue use and contact your clinician if you develop irritation, rash or other unexpected reactions. Use only as directed by your clinician.
GHK-Cu Renewal Cream FAQs
What is GHK-Cu Renewal Cream?
What is GHK-Cu?
How is this different from a drugstore copper-peptide serum?
How long until I see results?
How much does it cost?
Do I need a prescription?
Is it FDA approved?
Ready for firmer, clearer skin?
Complete the 2-minute online intake to see if GHK-Cu Renewal Cream is right for you. A licensed clinician reviews every request.
See If It's Right For You From $109/month, clinician review and free shipping includedImportant FDA disclosure: The peptide medications and therapies offered have not been approved by the FDA. The FDA has not evaluated statements regarding the benefits of these therapies. These products are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. Use of compounded medications involves known and unknown risks that should be discussed with your clinician.
Medical disclaimer: Rx.com does not provide medical advice or prescribe medication. GHK-Cu Renewal Cream is available only after an evaluation by a licensed clinician. Product details, formulation and pricing are provided by System Labs and may change.
Affiliate disclosure: Rx.com may earn a commission if you start treatment through links on this page, at no additional cost to you.