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Fluocinolone Acetonide Bottle — prescription drug image

Fluocinolone Acetonide

Fluocinolone Acetonide 20ML of 0.01%

What is Fluocinolone Acetonide?

Fluocinolone acetonide is a potent synthetic corticosteroid used primarily to reduce inflammation in various skin disorders, such as eczema and psoriasis. It is available in various forms, including creams, ointments, and oils, providing targeted relief by decreasing swelling, redness, and itching. This medication works by activating natural substances in the skin to suppress immune responses and inflammation.

Prescription savings · · · ·

What is Fluocinolone Acetonide ?

Fluocinolone acetonide is a potent synthetic corticosteroid used primarily to reduce inflammation in various skin disorders, such as eczema and psoriasis. It is available in various forms, including creams, ointments, and oils, providing targeted relief by decreasing swelling, redness, and itching. This medication works by activating natural substances in the skin to suppress immune responses and inflammation.
  • Red or swollen skin.
  • Pus or blisters on the skin.
  • Acne.
  • Burning, itching, or peeling skin.
  • If you are pregnant or breastfeeding, talk to your doctor before using this medicine.
  • You should not use this medicine for a longer period of time than your doctor ordered.
  • Before using this medicine, let your doctor know if you have diabetes, a stomach ulcer, or tuberculosis (TB).
  • Call your doctor if your symptoms get worse, or do not clear up after 7 days of treatment.
  • You may be more likely to have side effects from this medicine if you are over 60 years of age.
What is fluocinolone acetonide cream used for?
Fluocinolone acetonide cream is FDA-approved to relieve the inflammation and itching of corticosteroid-responsive skin conditions. In practice that most often means eczema (atopic dermatitis), psoriasis, seborrheic dermatitis, contact dermatitis, and lichen planus. It is a corticosteroid, so it calms the immune reaction in the skin that causes redness, swelling, scaling, and itch. It does not treat skin infections, and it should not be used on an infection that is not being treated.
Is fluocinolone acetonide a strong steroid?
It is generally considered a low-to-medium potency topical corticosteroid, not one of the strongest. Where it lands depends on the strength (0.01% or 0.025%) and the vehicle, since an ointment delivers more steroid effect than a solution, oil, or shampoo. It is milder than high-potency steroids such as fluocinonide or clobetasol propionate. Even so, potency alone does not tell you how safe it is for you; how much you use, where you put it, and for how long all matter, so follow your prescriber's directions.
How long can you safely use fluocinolone acetonide on your skin?
Use it only for as long as your prescriber tells you to. The labeling advises stopping the medicine once the condition is under control, and reassessing the diagnosis if the rash has not improved. Longer continuous use, larger treated areas, covering the skin with dressings, and applying it to broken skin all raise the chance of side effects such as skin thinning, stretch marks, and absorption of enough steroid to affect the body's own hormone system. Children are more sensitive to that absorption. If you feel you need it for weeks on end, that is a conversation to have with your provider rather than something to manage on your own.
Can you put fluocinolone acetonide on your face?
Not unless your provider specifically directs it. The label says to avoid the eyes, face, groin, and underarms unless instructed, because facial skin is thin and absorbs more steroid, which raises the risk of thinning, acne-like breakouts, and skin color changes. There is an exception: Tri-Luma, a combination cream containing fluocinolone acetonide 0.01% with hydroquinone and tretinoin, is a distinct product approved for melasma of the face and is used under a provider's supervision. Do not substitute plain fluocinolone cream for it on your own.
What is the difference between fluocinolone and triamcinolone?
Both are synthetic corticosteroids applied to the skin for steroid-responsive rashes, and both are available as generics, so they are used for very similar conditions. The main differences are potency and available forms. Fluocinolone acetonide is generally low-to-medium potency at its common 0.01% and 0.025% strengths, and it comes as a cream, ointment, topical solution, body and scalp oil, and shampoo. Triamcinolone acetonide is commonly used at medium potency and comes in creams, ointments, lotions, and a spray. Which one is right for you depends on the rash, the part of the body, and your prescriber's judgment. Prices differ between them and between pharmacies, so it is worth comparing whichever one you are prescribed.
How much does Fluocinolone Acetonide cost without insurance?
The price of Fluocinolone Acetonide without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 87% off retail prices with a free Rx.com coupon.
What are the common side effects of Fluocinolone Acetonide?
Common side effects of Fluocinolone Acetonide may include: Red or swollen skin., Pus or blisters on the skin., Acne., Burning, itching, or peeling skin.. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Fluocinolone Acetonide?
Generic versions may be available for Fluocinolone Acetonide. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Fluocinolone Acetonide on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Fluocinolone Acetonide?
The cheapest pharmacy for Fluocinolone Acetonide depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Fluocinolone Acetonide near you.

Fluocinolone Acetonide Coupons & Prices

Fluocinolone Acetonide 20ML of 0.01%

Fluocinolone Acetonide Bottle — prescription drug image
Prescription
Fluocinolone Acetonide 60ml of 0.01% (0.5)
your area ·

Fluocinolone Acetonide prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
0.5gm of · Bottle 30 $8,543.99 $7,107.24
1gm of · Bottle 60 $4,833.49
5gm of · Bottle 60 $3,746.54
10gm of · Bottle 10 $2,904.49 $2,372.35
25gm of · Bottle 60 $14,209.08
60ml of 0.01% · Bottle 60 $187.50 $25.05

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

A fluocinolone acetonide coupon from Rx.com can lower what you pay at the pharmacy counter for this common prescription corticosteroid, which is used to calm the redness, swelling, and itching of steroid-responsive skin conditions such as eczema, psoriasis, seborrheic dermatitis, and contact dermatitis. Fluocinolone acetonide is the generic form of brands like Synalar, and generics are usually the lower-cost way to fill it, but the cash price still swings a lot from one pharmacy to the next, and the cream, ointment, solution, oil, and shampoo forms are all priced differently. Enter your ZIP code above to compare today's fluocinolone acetonide price across more than 60,000 pharmacies and print, text, or email your free discount card before you go.

What is fluocinolone acetonide and how does it work?

Fluocinolone acetonide is a synthetic fluorinated corticosteroid (a glucocorticoid) applied to the skin or scalp. Corticosteroids work by quieting the inflammatory response in the skin, which eases the redness, swelling, scaling, and itching that come with steroid-responsive skin conditions. It is FDA-approved for the relief of the inflammatory and itching manifestations of corticosteroid-responsive dermatoses, which in everyday terms most often means eczema (atopic dermatitis), psoriasis, seborrheic dermatitis, contact dermatitis, and lichen planus.

It comes in several forms, each with its own approved use:

  • Cream, ointment, and topical solution (0.01% and 0.025%) - for corticosteroid-responsive skin conditions; sold generically and under the brand Synalar.
  • Topical oil 0.01% (Derma-Smoothe/FS) - a body oil indicated for atopic dermatitis in adults and children, and a scalp oil indicated for psoriasis of the scalp in adults.
  • Shampoo 0.01% (Capex) - indicated for seborrheic dermatitis of the scalp.
  • Combination cream (Tri-Luma) - fluocinolone acetonide 0.01% combined with hydroquinone and tretinoin, for melasma of the face.

A completely separate product line of fluocinolone acetonide intravitreal implants is used by eye specialists for diabetic macular edema and chronic non-infectious uveitis of the back of the eye. Those are surgical eye products, not the topical skin medicines most people are searching for, and they are priced and dispensed very differently.

Fluocinolone acetonide cost and coupon savings

Fluocinolone acetonide is available as an FDA-approved generic, so it is already one of the more affordable prescription topical steroids, and most people paying cash will do better with the generic than with a brand such as Synalar, Capex, or Derma-Smoothe/FS. There is no manufacturer copay savings card for the generic. But "generic" does not mean "one price": the cash price for the same tube or bottle can differ substantially between two pharmacies on the same street, and it also depends on the form (cream and ointment are typically cheaper than the oil, shampoo, or combination cream), the strength, and the package size your prescription calls for.

That variation is exactly why comparing matters. Rx.com checks fluocinolone acetonide prices at more than 60,000 U.S. pharmacies, including the big chains, grocery and warehouse pharmacies, and independents, then shows you the discounted cash price at each one. Enter your ZIP code above to see today's price near you, and bring the free Rx.com coupon to the counter. The discount is for cash-paying customers and cannot be combined with insurance, so if you do have coverage, it is worth asking the pharmacist to run both and charge you whichever is lower. If your provider wrote for a specific form, ask whether a different form or a larger tube would cost less per use before you fill it.

How fluocinolone acetonide compares to other topical steroids

Topical corticosteroids are usually ranked by potency, and fluocinolone acetonide sits in the low-to-medium range depending on its strength (0.01% or 0.025%) and its vehicle (ointments push a given steroid to the stronger end, while solutions, oils, and shampoos are generally milder on the skin). That middle position is why prescribers often choose it for larger areas or for longer-running rashes, rather than reaching straight for a high-potency steroid.

Related topical corticosteroids your prescriber may consider, roughly from milder to stronger:

All of these are available as generics, and all of them vary in price by pharmacy, so if your prescriber gives you a choice it is worth comparing before you fill. Only your prescriber can decide which potency is right for your rash and the part of the body it is on.

Safety, side effects, and things to tell your provider

Topical fluocinolone acetonide has no boxed warning. The most common problems are local: burning, itching, irritation, dryness, folliculitis, acne-like eruptions, lightening of the skin, allergic contact dermatitis, and, with longer use, thinning of the skin (atrophy), stretch marks, and heat rash. Enough steroid can be absorbed through the skin to affect the body as a whole, which can cause reversible suppression of the hypothalamic-pituitary-adrenal (HPA) axis, Cushing's syndrome, high blood sugar, and sugar in the urine. That risk goes up with higher potency, treating a large area, using it for a long time, covering the area with occlusive dressings, or applying it to broken skin. Children absorb proportionally more because of their skin-surface-to-body-weight ratio, so they face a greater risk of HPA suppression and slowed growth.

Use it exactly as directed: do not bandage, cover, or wrap the treated area unless your provider tells you to, and avoid the eyes, face, groin, and underarms unless your provider specifically directs otherwise. Do not use it on an untreated skin infection, and let your provider know if a rash is not clearing or seems to be getting worse. The Derma-Smoothe/FS oil formulations contain refined peanut oil, so tell your provider if you have a peanut allergy. The intravitreal eye implant forms carry their own separate risks, including cataract, raised eye pressure or glaucoma, and eye infection. This page is general information, not medical advice; talk with your doctor or pharmacist about your specific condition, other medicines, and how long to use this one.

Sources & accuracy

This Fluocinolone Acetonide information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Fluocinolone Acetonide on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.